Nutritional Strategies to Augment the Postprandial Muscle Protein Synthetic Response to the Ingestion of a Low Dose of Protein in Middle-aged Women
Completed · Not applicable
Conditions studied: Aging
In brief
Using stable isotope methodology, investigators will determine the postabsorptive and postprandial muscle protein synthetic response in 60 female adults (Age 50-79, BMI: \<30 kg/m2) immediately after an acute bout of resistance exercise. Participants will be divided in to 5 groups of twelve women (n=12). Each group will receive a different protein beverage or placebo to consume following the resistance exercise training. Group 1 will consume a beverage consisting of whey protein; group 2 will consume whey protein supplemented with additional leucine; group 3 will consume whey protein supplemented with additional leucine and hydrolyzed whey peptides; group 4 will consume whey protein supplemented with additional leucine and citrulline; group 5 will just consume water. During the testing, blood and muscle samples will be collected.
Key facts
- Study ID
- NCT02918981
- Run by
- University of Illinois at Urbana-Champaign
- People needed
- 50
- Starts
- 2016-10-01
- Expected to finish
- 2019-03-06
- Last updated by the study team
- 2020-11-03
Who can join
Age: 20 and older, up to 79. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- BMI <30 kg/m2
- Healthy, sedentary
- Either 20-30 years old or 50-79 years old
You may not qualify if…
- Tobacco use
- Allergies to milk consumption
- Unusually high protein consumption
- Vegan diet
- Allergies to antibiotics or xylocaine
- Phenylketonuria (PKU)
- Diagnosed GI tract diseases
- Arthritic conditions
- A history of neuromuscular problems
- Heart disease
- Metabolic disorders
- -Liver, kidney, or urinary disease
- Musculoskeletal problems
- Autoimmune disease
- Neurological disease
- Previous participation in amino acid tracer studies
- Predisposition to hypertrophic scarring or keloid formation
- Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
- Individuals using thyroid medications or other medications affecting endocrine function
- Pregnancy
- Contraindications for exercise
- BMI ≥30
- supplements that influence protein metabolism (e.g omega 3 fish oils)
Where it is running
- Freer Hall — Urbana, Illinois, United States
Full record on ClinicalTrials.gov
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