Oedema Study : Chroedem

Recruiting now

Conditions studied: Lower Limb Chronic Oedema

In brief

The chroedem study is aiming to assess tissue and biomolecular components of chronic lower limb oedema (CO). The investigators working hypothesis is that according to the aetiology of CO, the proportion of oedema \& composition of peri-oedema tissues (fat, muscle, fibrosis/inflammation) might differ and could at least in part explain differences in failure/success of compressive therapies from one patient to another. For that purpose, 24 patients with a post-thrombotic syndrome (PTS)-related oedema and 24 patients with a primary lymphedema will undergo a magnetic resonance imaging (MRI)) of the legs and biological (genetic) testing.

Key facts

Study ID

NCT02914808

Run by

University Hospital, Montpellier

People needed

60

Starts

2017-01-03

Expected to finish

2026-07-01

Last updated by the study team

2025-10-03

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Lower limb CO secondary to PTS or Primary lymphoedema (We will include secondary lymphedema of the lower limbs only if the matcing constraints on age and length of evolution do not allow pairing)

You may not qualify if…

• Bilateral CO
• Obesity
• Mixed CO (PTS and lymphatic origins)
• CO of other origin : Heart failure, hepatic or renal impairment
• Denutrition
• Contra-indication to MRI
• Patient not affiliated to French Health Insurance System
• Patient protected by the law
• Patient refusing to participate

Where it is running

• University Hospital of Montpellier — Montpellier, France (enrolling)
• Pr Sophie BLAISE — Grenoble, Isère, France
• University Hospital Nimes — Nîmes, France

Full record on ClinicalTrials.gov

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