Cannabinoid Medication for Adults With OCD
Completed · Phase 1/Phase 2
Conditions studied: Obsessive-Compulsive Disorder
In brief
The purpose of this pilot research study is to test the effects of a medication called nabilone (Cesamet) in adults with obsessive-compulsive disorder (OCD). Participants will receive either nabilone on its own, or nabilone in combination with a form of cognitive-behavioral therapy (CBT) called exposure and response prevention (EX/RP). Nabilone is a synthetic cannabinoid and acts on the brain's "endocannabinoid system," which has been hypothesized to play a role in OCD. Nabilone is approved by the FDA for the treatment of chemotherapy-induced nausea and vomiting. It is not FDA-approved for treating OCD.
Key facts
- Study ID
- NCT02911324
- Run by
- New York State Psychiatric Institute
- People needed
- 16
- Starts
- 2016-09-01
- Expected to finish
- 2019-01-01
- Last updated by the study team
- 2020-08-06
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-60
- Physically healthy, not pregnant
- Primary Obsessive-Compulsive Disorder (OCD)
- Patient off all psychotropic (except selective serotonin reuptake inhibitors [SSRIs]) and other types of drugs likely to interact with nabilone
- Ability to provide informed consent
- Ability to tolerate a treatment free-period
You may not qualify if…
- History of any significant medical condition that may increase the risk of participation
- Females who are pregnant or nursing
- Current or lifetime history of psychiatric disorders other than OCD that may increase the risk of participation (e.g. lifetime psychosis or bipolar disorder)
- Current substance use disorder or positive urine toxicology at screening, or any adverse reaction to a cannabinoid
- Patients already receiving EX/RP
Where it is running
- New York State Psychiatric Institute — New York, New York, United States
Full record on ClinicalTrials.gov
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