Retinol on Human Skin Aging in East Asian Descent
Completed · Phase 4 · Has a placebo group
Conditions studied: Intrinsic Aging of Skin
In brief
There has been increasing evidence for different rates of natural aging in humans and one of the best organs to study human aging is skin. Studies have demonstrated anti-aging effects of topical agents (such as creams, gels, lotions, or ointments) and one of them, retinol or vitamin A, was shown to decrease fine wrinkling in skin of older individuals. Additionally, studies of retinol in humans have largely occurred in white populations and so this study aims to focus on skin aging in individuals of East Asian descent as they represent a majority of the world population. This study aims to better characterize the molecular basis of rejuvenation effects and to potentially discover new topical agents with similar and/or more effective preservation of skin youthfulness.
Key facts
- Study ID
- NCT02906566
- Run by
- Stanford University
- People needed
- 110
- Starts
- 2015-11-01
- Expected to finish
- 2018-03-09
- Last updated by the study team
- 2019-04-16
Who can join
Age: 18 and older, up to 75. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- able to provide written informed consent
- older group: age between 50 and 75 years
- young group: age 18 to 25 years
- all four grandparents of Han Chinese, Japanese, Korean descent
- body mass index within normal or overweight range
- no history of weight loss of >20 lbs within past 5 years
You may not qualify if…
- skin condition in the areas of skin biopsy that would obscure results of analysis
- topical creams or treatment to arms 2 weeks prior to study baseline visit
- individuals with known hypersensitivity to retinoid class of agents (older group only)
- prior anti-aging treatments to arms including retinol, microdermabrasion within 2 weeks of baseline visit
- prior laser therapy or surgical procedure to arms
- prior radiation or other trauma (extensive burns or abrasions) to arm skin
- hormone-based therapy within 4 weeks of enrollment
Where it is running
- Stanford Dermatology — Redwood City, California, United States
Full record on ClinicalTrials.gov
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