Heart Attack Research Program- Imaging Study

Running, not enrolling

Conditions studied: Myocardial Infarction

In brief

The HARP study is a multi-center, diagnostic observational study employing standardized imaging protocols in patients with MINOCA (MI with Non Obstructive Coronary Arteries) to determine the underlying diagnosis in each participant. Participants will be followed for recurrent clinical events, every 6 months, for a maximum of 10 years.

Key facts

Study ID

NCT02905357

Run by

NYU Langone Health

People needed

450

Starts

2016-09-12

Expected to finish

2027-06-30

Last updated by the study team

2026-03-19

Who can join

Age: 21 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Acute ischemic symptoms compatible with diagnosis of MI, such as chest pain or anginal equivalent symptoms at rest or new onset exertional anginal equivalent symptoms
• Objective evidence of MI (either or both of the following):
• Elevation of troponin to above the laboratory upper limit of normal
• ST segment elevation of ≥1mm on 2 contiguous ECG leads
• Willing to provide informed consent and comply with all aspects of the protocol
• Age ≥ 21 years

You may not qualify if…

• Stenosis ≥50% of any major epicardial vessel on invasive angiography, as determined by the angiographer at the time of clinically ordered cardiac catheterization
• History of known obstructive coronary artery disease at angiography, including history of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG)
• Recent use of vasospastic agents, such as cocaine, triptans, or ergot alkaloids (≤1 month)
• Alternate explanation for troponin elevation, such as hypertensive urgency, acute exacerbation of heart failure, chronic elevation due to kidney disease, pulmonary embolism, cardiac trauma
• Coronary dissection apparent on angiography
• Excessive coronary tortuosity which, in the angiographer's opinion, increases the risks of OCT
• eGFR<45 or contraindication to additional contrast needed for OCT in the opinion of the angiographer or treating physician
• Contraindication to MRI (including but not limited to ferromagnetic implants)
• Pregnancy
• Thrombolytic therapy for STEMI (qualifying event)

Where it is running

• University of Alabama-Birmingham — Birmingham, Alabama, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• UC San Diego Medical Center — San Diego, California, United States
• Stanford University — Stanford, California, United States
• University of Florida Medical Center — Gainesville, Florida, United States
• Emory University — Atlanta, Georgia, United States
• Johns Hopkins Medical Center — Baltimore, Maryland, United States
• Dartmouth-Hitchcock — Lebanon, New Hampshire, United States
• NYU Winthrop — Mineola, New York, United States
• NYU Langone Medical Center — New York, New York, United States
• Columbia University Medical Center/NYPH — New York, New York, United States
• Ohio State University Medical Center — Columbus, Ohio, United States
• St. Luke's University Health Network — Bethlehem, Pennsylvania, United States
• University of Pittsburgh Medical Center — Pittsburgh, Pennsylvania, United States
• Seton Heart (Ascension) Univeristy of Austin, Texas — Austin, Texas, United States
• University of Alberta — Edmonton, Alberta, Canada
• Vancouver General Hospital — Vancouver, British Columbia, Canada
• St. Boniface General Hospital — Winnipeg, Manitoba, Canada
• University of Calgary — Calgary, Canada
• Golden Jubilee National Hospital — Clydebank, Scotland, United Kingdom

Full record on ClinicalTrials.gov

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