Efficacy Study of Acetazolamide Versus Diazepam in Continuous Spike and Wave/Landau-Kleffner Syndrome

Stopped early · Phase 2/Phase 3

Conditions studied: Landau-Kleffner Syndrome, Status Epilepticus, Electrographic

In brief

The purpose of this study is to compare the effectiveness of the medications acetazolamide and diazepam in the treatment of continuous spike wave in sleep (CSWS) and Landau-Kleffner syndrome (LKS).

Key facts

Study ID

NCT02904265

Run by

Mayo Clinic

People needed

3

Starts

2016-09-01

Expected to finish

2019-07-26

Last updated by the study team

2020-06-11

Who can join

Age: 3 and older, up to 12. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• ESES and clinical CSWS/LKS defined by all of the following:
• SWI ≥50% during first hour of sleep
• Bilateral synchrony of discharges during sleep
• Clinical evidence of behavior and/or academic regression
• Daytime SWI ≤20%

You may not qualify if…

• Previous treatment with benzodiazepine or acetazolamide for Electrical Status Epilepticus in Sleep (ESES)
• Current treatment with carbamazepine, phenytoin, oxcarbazepine, phenobarbital, vigabatrin or lamotrigine
• Antiepileptic medication changes over the month prior to enrollment
• Epileptic encephalopathy other than CSWS/LKS
• Prior serious adverse reaction to benzodiazepines or acetazolamide
• Sulfa allergy
• Progressive underlying neurologic condition
• Frequent seizures that would prevent the patient from maintaining a stable dose of medications
• Female patient that has begun menses or is pregnant

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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