Brain Morphometry in OA Patients Treated With Duloxetine

Completed · Not applicable · Has a placebo group

Conditions studied: Pain, Osteoarthritis

In brief

This is a two week,single-blind study evaluating pain response and changes in brain imaging upon treatment with placebo in people with knee OA.

Key facts

Study ID

NCT02903238

Run by

Northwestern University

People needed

21

Starts

2011-07-01

Expected to finish

2011-12-01

Last updated by the study team

2017-03-07

Who can join

Age: 40 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age: 40-85 years
• ACR criteria for OA including Kellgren-Lawrence radiographic OA grades II-IV
• VAS pain score >5/10 within 48 hrs of the phone screen and visit 1 (Screening)
• Knee OA for a minimum of 12 months
• Need for daily pain medication to manage symptoms of OA

You may not qualify if…

• Currently taking MAO inhibitors or any centrally acting drug for analgesia
• Narrow angle glaucoma
• Uncontrolled hypertension
• Co-existing inflammatory arthritis, fibromyalgia or other chronic pain state
• If a female, pregnant, trying to become pregnant, or lactating
• Major depressive disorder
• Substantial alcohol use or history of significant liver disease
• Diabetes, type 1 or type 2
• Condition in which the Investigator believes would interfere with the subject's ability to comply with study instructions, or might confound the interpretation of the study results or put the subject at undue risk
• Standard MRI safety exclusions

Where it is running

• Northwestern University Feinberg School of Medicine — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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