Synovitis and Therapy Response in Inflammatory Arthritis With Contrast Enhanced Ultrasound

Completed · Not applicable

Conditions studied: Synovitis, Rheumatoid Arthritis

In brief

This study is about using contrast-enhanced ultrasound (CEUS) to assess the degree of synovitis (joint inflammation) in patients with inflammatory arthritis, such as rheumatoid arthritis, and whether it can be used for assessing a treatment response. The investigators hope to learn whether contrast enhanced ultrasounds are better than regular imaging techniques, such as MRI, when used to evaluate the response to disease modifying anti-rheumatic drug (DMARD) therapy in inflammatory arthritis.

Key facts

Study ID

NCT02902562

Run by

University of Southern California

People needed

16

Starts

2016-08-31

Expected to finish

2018-08-22

Last updated by the study team

2019-04-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients (≥ 18 years of age) that meet diagnostic criteria for an inflammatory arthritis.
• Clinical suspicion of active synovitis involving at least one target joint.
• Patients competent to sign study specific Informed Consent.
• Patients willing to comply with protocol requirements.
• Intent to treat with disease-modifying anti-rheumatic drugs (DMARDs).

You may not qualify if…

• Patients who are pregnant or less than 18 years of age.
• Patients who have a known cardiac shunt or pulmonary hypertension.
• Patients with any known hypersensitivity to perflutren or gadolinium contrast agents or renal insufficiency (GFR < 30 mL/min).
• Patients who cannot consent for themselves.

Where it is running

• USC Department of Radiology — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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