Phase II MEDI4736 in Combination With Chemotherapy for First-Line Treatment of Unresectable Mesothelioma
Completed · Phase 2
Conditions studied: Mesothelioma, Pleural Mesothelioma
In brief
Patients with pleural mesothelioma that can not be surgically removed will receive durvalumab, in combination with standard chemotherapy of pemetrexed and cisplatin as first-line treatment. Durvalumab is a type of drug called a monoclonal antibody (a type of protein). Laboratory tests show that it works by allowing the immune system to detect your cancer and reactivates the immune response. This may help to slow down the growth of cancer or may cause cancer cells to die. The purpose of this study is to see whether adding durvalumab to standard chemotherapy will improve overall survival (OS).
Key facts
- Study ID
- NCT02899195
- Run by
- PrECOG, LLC.
- People needed
- 55
- Starts
- 2017-06-13
- Expected to finish
- 2023-06-29
- Last updated by the study team
- 2023-07-05
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University San Diego Moores Cancer Center — La Jolla, California, United States
- Ronald Reagan UCLA Medical Center — Los Angeles, California, United States
- Stanford Cancer Institute — Stanford, California, United States
- University of Colorado, Anschutz Cancer Pavilion — Aurora, Colorado, United States
- University of Miami Hospital — Miami, Florida, United States
- Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
- University of Chicago Medical Center — Chicago, Illinois, United States
- NorthShore University HealthSystem — Evanston, Illinois, United States
- Johns Hopkins Sidney Kimmel Comprehensive Cancer Center — Baltimore, Maryland, United States
- St. Joseph Mercy Hospital — Ann Arbor, Michigan, United States
- Metro Minnesota Community Oncology Research Consortium — Saint Louis Park, Minnesota, United States
- Washington University in St Louis — St Louis, Missouri, United States
- Rutgers Cancer Institute of New Jersey — New Brunswick, New Jersey, United States
- New York University Laura and Isaac Perlmutter Cancer Center — New York, New York, United States
- Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
- Hillman Cancer Center Research Pavilion — Pittsburgh, Pennsylvania, United States
- UTSW Medical Center — Dallas, Texas, United States
- Virginia Cancer Specialists — Fairfax, Virginia, United States
- University of Washington Seattle Cancer Care Alliance — Seattle, Washington, United States
- Aurora Cancer Center — Wauwatosa, Wisconsin, United States
Full record on ClinicalTrials.gov
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