Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers, Study 1

Completed · Phase 1

Conditions studied: Malaria

In brief

To investigate the comparative tolerability, metabolism and pharmacokinetics of individual enantiomers of PQ in healthy human volunteers. The specific aim is the comparative evaluation of the metabolism, pharmacokinetic behavior, and tolerability of the isomers of PQ (RPQ and SPQ and the racemic mixture RSPQ) in normal healthy human volunteers.

Key facts

Study ID

NCT02898779

Run by

University of Mississippi, Oxford

People needed

36

Starts

2017-05-01

Expected to finish

2018-03-01

Last updated by the study team

2018-05-15

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults (18-60 years of age)
• Informed consent
• Healthy

You may not qualify if…

• Known history of liver, kidney or hematological disease;
• known history of cardiac disease, arrhythmia, QT prolongation;
• Autoimmune disorder;
• Report of an active infection;
• Evidence of G6PD deficiency

Where it is running

• University of Mississippi — Oxford, Mississippi, United States

Full record on ClinicalTrials.gov

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