Transcutaneous Oxygen as a Predictor of Wound Healing Complications in Preoperatively Radiated Soft Tissue Sarcoma

Completed

Conditions studied: Sarcoma, Soft Tissue

In brief

Wound complications after sarcoma resection are frequent and potentially devastating problem. The burden of surgical wound complications in the lower extremity after preoperative external beam radiation therapy (EBRT) for soft tissue sarcoma is estimated at 43%. A noninvasive method of predicting complications would be extremely beneficial. The aim of this study is to evaluate the relationship between preoperative skin oxygenation and wound outcomes in a multi-center prospective analysis. This information could lead to a change in practice regarding surgical timing and adjunctive interventions to improve wound healing outcomes.

Key facts

Study ID

NCT02897128

Run by

The Cleveland Clinic

People needed

39

Starts

2016-07-01

Expected to finish

2021-01-15

Last updated by the study team

2021-07-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• age > 18
• biopsy proven soft tissue sarcoma of the lower extremity (pelvic area and below)
• plan for preoperative radiation and limb sparing resection

You may not qualify if…

• upper extremity sarcoma
• recurrent soft tissue sarcoma
• prior surgery in the area of the sarcoma
• prior radiation in the area of the sarcoma
• need for immediate skin graft or flap for coverage
• pregnant patients
• patients unwilling to have surgery or radiation

Where it is running

• University of Florida — Gainesville, Florida, United States
• University of Iowa Hospitals and Clinics — Iowa City, Iowa, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University of Oklahoma — Oklahoma City, Oklahoma, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.