Assessing Ocular Hemodynamic Response to Surgical Intervention in Glaucoma

Stopped early

Conditions studied: Primary Open Angle Glaucoma, Low Tension Glaucoma, Cataract, Ocular Hypertension

In brief

The purpose of this study is to assess how surgical interventions in glaucoma affect 24-hour intraocular pressure, 24-hour ocular perfusion pressure, optic nerve blood flow, and retinal oxygen saturation.

Key facts

Study ID

NCT02891317

Run by

University of North Carolina, Chapel Hill

People needed

2

Starts

2017-05-08

Expected to finish

2017-06-12

Last updated by the study team

2019-03-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participants meeting the following surgical indications for glaucoma:
• Open angle glaucoma with uncontrolled intraocular pressure on maximum tolerated medical therapy at risk of glaucomatous vision loss, documented visual field progression, severe visual field defects threatening or involving fixation with preserved visual acuity
• Phacomorphic angle closure with clinical symptoms and/or Visual Field/Optical Coherence Tomography defects
• Other appropriate indication
• Participants willing to complete the written informed consent
• Participants willing to complete a screening visit and subsequent study visits

You may not qualify if…

• Children and adolescents
• Patients with non-phacomorphic angle closure or secondary glaucoma diagnosis
• Prior retinal or glaucoma laser or incisional surgeries
• Non-glaucomatous optic neuropathy
• Any intraocular surgery within the preceding 90 days
• Active ocular infection or inflammation
• Ocular abnormalities that preclude the necessary study related measurements and assessments
• Pre-existing medical conditions that are associated with blood pressure (BP) instability
• Medications that confound BP assessment
• Symptomatic dry eye disease
• Allergy to silicone, adhesives, diagnostic and post-surgical topical ocular medications
• Skin irritation, eczema, or other indication against wearing patches
• Vulnerable populations

Where it is running

• UNC Kittner Eye Center — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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