The Effect of Ibuprofen on Post-partum Blood Pressure in Women With Hypertensive Disorders of Pregnancy
Completed · Phase 4
Conditions studied: Hypertension, Pregnancy-Induced, Pre-eclampsia
In brief
To assess the effect of routine doses of ibuprofen on post-partum blood pressure control in women with gestational hypertension (gHTN) or preeclampsia without severe features (preE).
Key facts
- Study ID
- NCT02891174
- Run by
- University of Michigan
- People needed
- 74
- Starts
- 2016-12-01
- Expected to finish
- 2018-06-20
- Last updated by the study team
- 2019-05-23
Who can join
Age: 18 and older, up to 45. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Antepartum women
- Diagnosis of Gestational Hypertension or Pre-eclampsia by blood pressure ≥140 systolic or ≥90 diastolic, on at least 2 measurements ≥ 4 hours apart; with or without proteinuria (urine protein-creatinine ratio ≥0.3 or 24 hour-urine protein ≥300 mg).
- Taking one or fewer oral medications for blood pressure control.
- Singleton gestation.
- English-speaking
You may not qualify if…
- Allergy to nonsteroidal anti-inflammatory drugs, aspirin, or acetaminophen
- More than 1 severe range blood pressure (≥160 systolic or ≥110 diastolic) prior to enrollment.
- Neurologic symptoms attributed to hypertension (headache, visual changes) prior to enrollment.
- Pulmonary edema.
- Elevated AST (>60 international units/L) or ALT (>70 international units/L) prior to enrollment.
- Low platelet count (<100,000/microliter) prior to enrollment.
- Renal insufficiency (creatinine > 1.1 or double the baseline creatinine if known) prior to enrollment.
- Chronic hypertension defined as hypertension pre-existing pregnancy or diagnosed prior to 20-weeks' gestation.
- Moderate- or severe-persistent asthma.
- Therapeutic anticoagulation.
- Chronic opiate use during the pregnancy (opiate therapy given daily for > 2 weeks).
- Lactose intolerance or allergy due to placebo containing lactose.
- Cesarean delivery.
- Additional anesthesia at time of delivery (spinal anesthesia, sedation) that would change routine pain management.
Where it is running
- University of Michigan — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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