Effect of Hyperbaric Oxygen on Functional Connectivity in Patients With Cerebral Small Vessel Disease

Stopped early · Not applicable

Conditions studied: Cerebral Small Vessel Diseases

In brief

Patients will have a Functional MRI before and after 10 hyperbaric Oxygen treatments.

Key facts

Study ID

NCT02890888

Run by

St. Luke's Hospital, Chesterfield, Missouri

People needed

6

Starts

2014-11-01

Expected to finish

2017-10-25

Last updated by the study team

2017-10-27

Who can join

Age: 50 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• White Matter Hyperintensities on MRI
• 2 or more neurological symptoms or impairments e.g. gait disturbances, disequilibrium, cognitive decline, dysmetria, hyper-rflexia

You may not qualify if…

• Contraindication to hyperbaric oxygen treatment e.g. pulmonary emphysema, seizure disorder
• major eustachian tube dysfunction
• stroke with previous 6 months
• extreme cognitive impairment
• major depression
• history of migraine, electroshock therapy, brain irradiation, brain tumor, head trauma
• other uncontrolled co-morbidities, e.g. diabetes, renal or hepatic dysfunction, hypertension, thyroid disorders, carotid artery stenosis (>70%)

Where it is running

• St. Luke's hospital — Chesterfield, Missouri, United States
• St. Luke's Hospital — St Louis, Missouri, United States
• Mallinckrodt Institute of Radiology/Washington University Medical School — St Louis, Missouri, United States

Full record on ClinicalTrials.gov

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