The Innervation of Human Gut Sensory Epithelial Cells

Completed

Conditions studied: Organoids

In brief

The study has two objectives: 1. To obtain endoscopic and colonoscopic biopsies to harvest and culture intestinal crypts from human tissue to produce organoids. These organoids will be used to study the biology of innervated sensory epithelial cells. 2. to collect subject data relating to clinical management and demographic characteristics of patients undergoing upper endoscopy or colonoscopy to learn the mechanisms behind visceral hypersensitivity, and neurodegenerative diseases that may arise in the gut.

Key facts

Study ID

NCT02888587

Run by

Duke University

People needed

42

Starts

2017-09-05

Expected to finish

2022-12-01

Last updated by the study team

2023-01-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• All patients undergoing either endoscopy OR colonoscopy OR both procedures will be eligible for inclusion in this study.
• adult males and females 18 years of age or older who have been seen by the GI clinic or who have been scheduled for direct-to-procedure appointment in the GI clinic.

You may not qualify if…

• Subjects who are not competent to give consent
• Males and females under 18 years of age
• Women who are pregnant

Where it is running

• Duke Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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