Efficacy and Safety of LCZ696 Compared to Valsartan on Cognitive Function in Patients With Chronic Heart Failure and Preserved Ejection Fraction

Completed · Phase 3 · Has a placebo group

Conditions studied: Chronic Heart Failure (CHF)

In brief

This study was a multi-center, randomized, double-blind, parallel group, active comparator trial designed to evaluate the overall effect of LCZ696 compared to valsartan on cognitive function as assessed by the CogState comprehensive cognitive battery in patients with Heart failure and preserved ejection fraction (HFpEF).

Key facts

Study ID

NCT02884206

Run by

Novartis Pharmaceuticals

People needed

592

Starts

2016-11-23

Expected to finish

2022-05-16

Last updated by the study team

2024-08-06

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Novartis Investigative Site — Glendale, Arizona, United States
• Novartis Investigative Site — Mesa, Arizona, United States
• Novartis Investigative Site — Phoenix, Arizona, United States
• Novartis Investigative Site — Sun City West, Arizona, United States
• Novartis Investigative Site — Tucson, Arizona, United States
• Novartis Investigative Site — Beverly Hills, California, United States
• Novartis Investigative Site — Fresno, California, United States
• Novartis Investigative Site — Loma Linda, California, United States
• Novartis Investigative Site — Long Beach, California, United States
• Novartis Investigative Site — Newport Beach, California, United States
• Novartis Investigative Site — Santa Ana, California, United States
• Novartis Investigative Site — Santa Ana, California, United States
• Novartis Investigative Site — Torrance, California, United States
• Novartis Investigative Site — Danbury, Connecticut, United States
• Novartis Investigative Site — Clearwater, Florida, United States
• Novartis Investigative Site — Edgewater, Florida, United States
• Novartis Investigative Site — Hollywood, Florida, United States
• Novartis Investigative Site — Homestead, Florida, United States
• Novartis Investigative Site — Inverness, Florida, United States
• Novartis Investigative Site — Jacksonville Beach, Florida, United States
• Novartis Investigative Site — Miami, Florida, United States
• Novartis Investigative Site — Miami, Florida, United States
• Novartis Investigative Site — Miami, Florida, United States
• Novartis Investigative Site — Naples, Florida, United States
• Novartis Investigative Site — Andalusia, Alabama, United States

Full record on ClinicalTrials.gov

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