Guanfacine for PONV and Pain After Sinus Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Postoperative Nausea and Vomiting, Pain, Postoperative

In brief

Postoperative nausea and vomiting (PONV) and pain are the most common causes of Post Anesthesia Care Unit (PACU) discharge delay, with untreated PONV occurring in 20-30% of post-surgical patients. The effect of guanfacine (GF) administration on pain and nausea scores will be assessed with two groups. One group will receive 1 mg of GF to take orally and the other group will receive a similar appearing placebo (containing no drug) to take orally.

Key facts

Study ID

NCT02882854

Run by

Vanderbilt University Medical Center

People needed

84

Starts

2016-11-01

Expected to finish

2017-02-01

Last updated by the study team

2019-01-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• VUMC patients undergoing sinus surgery in MCE OR

You may not qualify if…

• Inability to read and freely consent
• Patients who take alpha-2 agonists routinely (guanfacine, clonidine, tizanidine)
• Patients undergoing sinus surgery planned for greater than 3 hours
• Patients with significant pre-existing pain, on chronic pain (opioid, methadone) therapy, severe fibromyalgia or other pre-existing pain condition in any body part
• Patients with preoperative nausea/vomiting at baseline.
• Pregnant or lactating women

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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