Effect of Diet on Gulf War Illness
Status unconfirmed · Not applicable
Conditions studied: Irritable Bowel Syndrome
In brief
Fermentable Oligo-, Di and Mono-saccharides And Polyols (FODMAPs) are carbohydrates that are poorly digested in intestines. The undigested carbohydrates are fermented in the colon by gut bacteria. Fermentation of these carbohydrates can lead to diarrhea, gas and distension of the colon. Low FODMAP diet effect may be mediated by changing the gut bacteria and/or by production of chemicals that influence Veteran's intestines which then result in reduced disease symptoms. The goal of this study is to compare a low FODMAP (modified healthy) diet to a high FODMAP (typical healthy) diet for effect on Veterans with IBS and symptoms of Gulf War illness.
Key facts
- Study ID
- NCT02881944
- Run by
- Ashok Tuteja
- People needed
- 68
- Starts
- 2016-08-01
- Expected to finish
- 2018-09-01
- Last updated by the study team
- 2018-02-01
Who can join
Age: 25 and older, up to 90. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Gulf War Veterans
- Men and women age 25-90 years
- Gulf War Illness: Veterans will have Rome III criteria for IBS and two or more of the non-intestinal symptom groups (chronic-once a week or more often-fatigue, insomnia, joint pains, general stiffness, and headache, neurological an mood, respirator and skin symptoms)
- Symptoms of > 6 months duration
- No significant findings on physical examination, complete blood count and clinical chemistry panel
- Normal gross appearance of the colonic mucosa (small colon polyps not an exclusion criteria)
- Veterans with psychological disorders will not be excluded but will be identified for sub-group analysis.
You may not qualify if…
- Current evidence of any lower gastrointestinal disorder such as celiac disease or inflammatory bowel disease
- Clinically significant chronic disease: HIV, cardiac, pulmonary, hepatic or renal dysfunction
- Presence of Giardia antigen, and Clostridium difficile toxin in stool
- Current history of drug or alcohol abuse
- Investigator perception of patient's inability to comply with study protocol
- Recent change in gastrointestinal medications
- Subject is currently participating in another research protocol. These subjects will be allowed to enroll after a washout period of one month.
Where it is running
- George E Wahlen VA Medical Center — Salt Lake City, Utah, United States (enrolling)
Full record on ClinicalTrials.gov
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