Immediate Effects of rTMS on Excitability of the Quadriceps With Knee Osteoarthritis
Completed · Not applicable · Has a placebo group
Conditions studied: Osteoarthritis, Knee
In brief
The purpose of the study is to identify things that influence the ability to "turn on" the thigh muscle (quadriceps). The thigh muscle tends to be under active with knee osteoarthritis, which may make it difficult to strengthen the muscle. The investigators are also testing a new technology called repetitive transcranial magnetic stimulation (rTMS) to determine whether it may help "turn up" activity in the under active thigh muscle immediately after its application. rTMS uses a targeted pulsed magnetic field, similar to what is used in an MRI (magnetic resonance imaging) machine to send an electrical signal from the brain to the thigh muscle.
Key facts
- Study ID
- NCT02881775
- Run by
- University of North Carolina, Chapel Hill
- People needed
- 20
- Starts
- 2016-09-01
- Expected to finish
- 2018-06-26
- Last updated by the study team
- 2019-06-11
Who can join
Age: 40 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- symptomatic knee osteoarthritis primarily involving one leg based on Western Ontario and McMaster Universities Arthritis Index (WOMAC) function subscale score > 10 (out of 100 points, indicating most dysfunction)
- diagnosis of knee osteoarthritis
- opposite knee with WOMAC pain score ≤ 5.
- opposite knee does not have a diagnosis of knee osteoarthritis
You may not qualify if…
- conditions affecting the leg other than osteoarthritis
- low blood pressure (< 90 systolic, 60 diastolic) or heart rate (< 60 beats per minute)
- conditions that limit exercise tolerance such as a heart condition
- pregnant or planning to become pregnant in the next 3 months
- conditions that alter sensation and pain processing
- BMI > 35
- severe arthritis in both knees
- history of leg or back surgery in the past year or knee replacement surgery;
- injection in the knee joint in the past 4 weeks
- requires an assistive device to walk
- any contraindications for TMS or rTMS (seizures, metal implants in head, brain related conditions, brain injury, drug or alcohol withdrawal)
- medications that lower seizure threshold
- history of fainting spells (syncope) or low blood pressure
- sleep deprived
- inability to understand and repeat back directions regarding the study
Where it is running
- University of North Carolina - Chapel Hill — Chapel Hill, North Carolina, United States
Full record on ClinicalTrials.gov
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