Investigating Gains in Neurocognition in an Intervention Trial of Exercise
Completed · Phase 3
Conditions studied: Healthy, Cognitive Function 1, Social
In brief
This randomized control trial will examine whether a 12 month monitored exercise intervention improves brain health in cognitively normal older adults. This trial will also address several important unanswered questions: (1) Are the recommended public health guidelines of 150 minutes/week of exercise sufficient for improving cognitive performance? (2) Does exercise influence brain structure and/or function? (3) Is there a dose-response effect of exercise on the above variables such that greater amounts of exercise brings about greater benefits in cognitive and brain health? (4) What are the mechanisms by which exercise influences brain health? and (5) What factors attenuate or magnify the effects of exercise on brain and cognitive health and contribute to the individual variability in intervention outcomes?
Key facts
- Study ID
- NCT02875301
- Run by
- University of Pittsburgh
- People needed
- 648
- Starts
- 2017-09-06
- Expected to finish
- 2023-04-11
- Last updated by the study team
- 2024-06-14
Who can join
Age: 65 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women 65 - 80 yrs
- Ambulatory without pain or the assistance of walking devices
- Able to speak and read English
- Exercise level of <60 minutes per week (less than 20 minutes / 3 days week)
- Medical clearance by PCP
- Living in community for duration of the study
- Reliable means of transportation
- No diagnosis of a neurological disease
- Eligible to undergo MRI
You may not qualify if…
- Current diagnosis of a DSM-V Axis I or II disorder including Major Depression
- History of major psychiatric illness including schizophrenia (not including general anxiety disorder or depression)
- Current treatment for cancer - except non-melanoma skin
- Neurological condition (MS, Parkinson's, Dementia, MCI) or brain injury (traumatic or Stroke)
- Type I Diabetes or insulin-dependent diabetes
- Current alcohol or substance abuse
- Current treatment for congestive heart failure, angina, uncontrolled arrhythmia, DVT or other cardiovascular event
- Myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac condition in the past year
- Regular use of an assisted walking device
- Presence of metal implants (pacemaker, stents) that would be MR ineligible
- Claustrophobia
- Color Blindness
- Not fluent in English
- Not medically cleared by PCP
- Engaging in >60 minutes of moderate intensity physical activity (more than 20 minutes day / 3 days per week)
- Traveling consecutively for 3 weeks or greater during the study
Where it is running
- University of Illinois — Champaign, Illinois, United States
- University of Kansas — Kansas City, Kansas, United States
- Northeastern University — Boston, Massachusetts, United States
- University of Pittsburgh — Pittsburgh, Pennsylvania, United States
- Carnegie Mellon University — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.