Non-Invasive TMS Neuromodulation for Enduring Balance & Locomotion Restoration in Parkinson's Disease
Withdrawn before enrolling · Not applicable
Conditions studied: Parkinson's Disease
In brief
This is a feasibility and exploratory pilot study of adjuvant transcranial magnetic stimulation (TMS) to physical therapy (PT) for locomotion and balance rehabilitation in Parkinson's disease patients.
Key facts
- Study ID
- NCT02875041
- Run by
- NYU Langone Health
- People needed
- 0
- Starts
- 2016-08-01
- Expected to finish
- 2018-05-02
- Last updated by the study team
- 2019-05-17
Who can join
Age: 35 and older, up to 89. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Diagnosis of PD confirmed by a neurologist with expertise in movement disorders;
- Hoehn and Yahr stage 2 to 4;
- On L-Dopa and/or Dopamine Agonist daily treatment regimen;
- On a stable medication regimen since at least 2 weeks prior the enrolment in the study and, in the view of the treating neurologist, unlikely to require medication adjustments in the following 3 months;
- Posture, locomotion and balance deficits requiring at least 10 sessions of PT.
You may not qualify if…
- History of seizure disorder, including febrile seizures, fainting spells or syncope of unknown cause(s);
- Neurological disorder other than PD including stroke (mild-to-moderate micro vascular disease is allowed), traumatic brain injury, brain tumors, hydrocephalus;
- Major or unstable medical illness;
- Pacemakers, neurostimulators, tattoos or metal foreign bodies in the head area (dental fillings are allowed);
- Untreated depression; or Beck Depression Inventory (BDI)>22
- Taking any of the following medications within the four weeks prior to the start of the study: imipramine, amitriptyline, doxepin, nortriptyline, maprotiline, bupropion, chlorpromazine, clozapine, foscarnet, ganciclovir, ritonavir, and theophylline;
- History of moderate or severe dementia, or history of Mini Mental State Examination (MMSE) <20 or Montreal Cognitive Assessment (MoCA) <22;
- Physical therapy treatment contraindications as determined by physiotherapist.
Where it is running
- New York University School of Medicine — New York, New York, United States
Full record on ClinicalTrials.gov
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