Open-Label Influenza Vaccine Evaluation

Completed · Not applicable

Conditions studied: Immune Response

In brief

This is an open-label, randomized trial in up to 210 adults aged 65-74 years to evaluate the immune response to consecutive influenza vaccination across 2 seasons. Participants will be randomized to receive 1 of 3 licensed and recommended vaccines in the first year; 2 arms will receive the same vaccination in the second year and the third arm will be randomized again to 1 of 3 licensed vaccines. All participants will have pre and post-vaccination serum blood draws for a total of 6 draws over 18 months.

Key facts

Study ID

NCT02872311

Run by

Marshfield Clinic Research Foundation

People needed

179

Starts

2016-09-01

Expected to finish

2018-09-01

Last updated by the study team

2025-12-10

Who can join

Age: 65 and older, up to 74. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 65-74 years at the time of study enrollment and are ambulatory and live in selected Wisconsin community or surrounding communities.
• Willing and able to give informed consent prior to study enrollment
• Able to comply with study requirements.

You may not qualify if…

• Prior receipt of 2016-17 influenza vaccine
• Current participation in another clinical trial
• Presence of a contraindication to influenza vaccine

Where it is running

• Marshfield Clinic - Marshfield Center — Marshfield, Wisconsin, United States

Full record on ClinicalTrials.gov

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