Open-label Study of Nelotanserin in Lewy Body Dementia With Visual Hallucinations or REM Sleep Behavior Disorder

Stopped early · Phase 2

Conditions studied: Lewy Body Dementia, Dementia With Lewy Bodies, Parkinson's Disease Dementia, Visual Hallucinations, REM Sleep Behavior Disorder

In brief

This study seeks to evaluate the long-term safety and effectiveness of nelotanserin for the treatment of visual hallucinations (VHs) and Rapid Eye Movement (REM) Sleep Behavior Disorder (RBD) in subjects with Lewy body dementia (LBD).

Key facts

Study ID

NCT02871427

Run by

Axovant Sciences Ltd.

People needed

80

Starts

2016-10-20

Expected to finish

2019-01-17

Last updated by the study team

2019-03-27

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with LBD who completed a previous nelotanserin VH or RBD study

You may not qualify if…

• Subjects with a current serious and/or unstable cardiovascular, respiratory, thyroid, gastrointestinal, renal, hematologic or other medical disorder

Where it is running

• US120 — Birmingham, Alabama, United States
• US143 — Little Rock, Arkansas, United States
• US114 — Boca Raton, Florida, United States
• US180 — Maitland, Florida, United States
• US154 — Ocala, Florida, United States
• US113 — Orlando, Florida, United States
• US152 — Ormond Beach, Florida, United States
• US107 — Indianapolis, Indiana, United States
• US132 — Lenexa, Kansas, United States
• US103 — Rochester, Minnesota, United States
• US129 — Lincoln, Nebraska, United States
• US101 — Chapel Hill, North Carolina, United States
• US147 — Fargo, North Dakota, United States
• US111 — Cincinnati, Ohio, United States
• US104 — Cleveland, Ohio, United States
• US105 — Columbus, Ohio, United States
• US173 — Lincoln, Rhode Island, United States
• US128 — Memphis, Tennessee, United States
• US131 — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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