Trial of Propranolol in Children and Youth With Autism Spectrum Disorder and Predictors of Response

Completed · Early Phase 1 · Has a placebo group

Conditions studied: Autism Spectrum Disorder

In brief

The purpose of this study is to find out how the brain of people with autism is affected by Propranolol. Propranolol is not FDA approved for the treatment of autism. Propranolol is FDA approved for the treatment of heart conditions such as blood pressure This research is being done because there are currently no drug treatment options for language impairments and social difficulties often experienced by people with autism.

Key facts

Study ID

NCT02871349

Run by

University of Missouri-Columbia

People needed

69

Starts

2016-08-01

Expected to finish

2020-08-01

Last updated by the study team

2020-10-08

Who can join

Age: 7 and older, up to 24. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Autism Spectrum Disorder diagnosis
• intelligence quotient (IQ) >= 85 (if aged 15-24), >= 75 (if aged 7-14)
• Native English speaker
• Parent or caregiver must older than 18 years and be a native English speaker

You may not qualify if…

• Taking Alpha 2 agonists
• Non-autism learning disorder
• Other major psychiatric disorders
• Other neurological disorders
• Major head trauma
• Reaction to adhesives
• Diabetes
• Reactive airway disease
• Thyroid disease
• Bradyarrhythmias
• Unexplained syncope
• Pregnancy
• Possible interacting drugs
• Underweight (<20kg if aged 7-14 years)
• Factors affecting ability to have an MRI (if aged 15-24 years)

Where it is running

• Thompson Center for Autism & Neurodevelopmental Disorders — Columbia, Missouri, United States

Full record on ClinicalTrials.gov

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