A Phase 1/2 Multicenter Dose Escalation and Expansion Study Of NKTR-214 In Subjects With Locally Advanced Or Metastatic Solid Tumors
Completed · Phase 1/Phase 2
Conditions studied: Unspecified Adult Solid Tumor, Protocol Specific
In brief
This is a first in human, open-label, sequential dose escalation and expansion Phase 1 study of NKTR-214 in adult patients with locally advanced or metastatic solid tumors.
Key facts
- Study ID
- NCT02869295
- Run by
- Nektar Therapeutics
- People needed
- 28
- Starts
- 2015-12-01
- Expected to finish
- 2018-10-31
- Last updated by the study team
- 2021-07-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologically confirmed diagnosis of a locally advanced or metastatic solid tumor.
- Received 1 or 2 prior lines of therapy.
- Life expectancy >12 weeks.
- Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1.
- Measurable disease per RECIST v1.1.
- Demonstrated adequate organ function within 14 days of treatment initiation.
- Subjects must be recovered from the effects of any prior chemotherapy, immunotherapy, other prior system anticancer therapy, radiotherapy or surgery.
- Women of childbearing potential must agree to use highly effective methods of birth control.
- All participants must agree to use double barrier contraception during study participation and for at least 2 months after the last dose of study drug.
- Additional criteria may apply.
You may not qualify if…
- Use of an investigational agent or an investigational device within 28 days before administration of first dose of NKTR-214.
- Females who are pregnant or breastfeeding.
- Participants who have an active autoimmune disease requiring systemic treatment within the past 3 months or have a documented history of clinically severe autoimmune disease that requires systemic steroids or immunosuppressive agents.
- Active central nervous system (CNS) metastases.
- Prior surgery or radiotherapy within 14 days of therapy.
- Participants who have had < 28 days since the last chemotherapy, immunotherapy, biological therapy, or < 14 days from approved tyrosine kinase inhibitor (TKI) therapy (sunitinib, sorafenib, vemurafenib, dabrafenib, cobimetinib), or systemic or inhaled steroid therapy at doses greater than 10mg of prednisone or equivalent before administration of the first dose of study medication.
- Participants' inability to adhere to or tolerate protocol or study procedures.
- Additional criteria may apply.
Where it is running
- Investigator Site - New Haven — New Haven, Connecticut, United States
- Investigator Site - Portland — Portland, Oregon, United States
- Investigator Site - Houston — Houston, Texas, United States
Full record on ClinicalTrials.gov
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