Anti-inflammatory Effects of the Fiber

Completed · Not applicable

Conditions studied: Type 2 Diabetes

In brief

This study will help elucidate the mechanism underlying the cardioprotective and anti-diabetes effect of dietary fiber by exploring a comprehensive set of inflammatory and oxidative stress markers, based on a contemporary understanding of this process. In addition, there have been very few studies that explored the immediate change in oxidative stress and incretin secretion after fiber intake. In this study, the investigators will be able assess the short term metabolic impact of dietary fiber at great details. The result will contribute to dietary recommendation or designing of fiber supplementation for prevention/treatment of diabetes, obesity and cardiovascular disease.

Key facts

Study ID

NCT02868788

Run by

University at Buffalo

People needed

10

Starts

2016-06-14

Expected to finish

2018-07-01

Last updated by the study team

2024-10-17

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Men and women 18 to 80 years of age
• Non-smoker (last cigarette at least one month ago)
• Type 2 diabetes for at least 1 year
• Body mass index > 30 kg/m2

You may not qualify if…

• Participation in any other concurrent clinical trials
• Pregnancy or premenopausal women who are trying to be pregnant
• Patients who are incompetent to give consent
• Patients on non-steroidal anti-inflammatory drugs or steroids
• Concurrent disease that could disrupt intestinal epithelium and increase permeability to endotoxin, ie Celiac and Crohns disease.
• Hepatic disease (transaminase > 3 times normal)
• Renal impairment (serum creatinine > 1.5 mg/dl)
• History of drug or alcohol abuse
• Use of over the counter or prescribed probiotic supplements.
• Recent or current antibiotic use.
• Coronary artery disease (CAD): documented by history of myocardial infarction, angioplasty/stent placement, angina, exercise EKG positive for ischemia or angiographic evidence of CAD

Where it is running

• ECMC Ambulatory Center, 3rd Floor — Buffalo, New York, United States

Full record on ClinicalTrials.gov

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