Acarbose Anti-aging Effects in Geriatric Subjects (Substudy B & C)
Completed · Phase 2
Conditions studied: Aging
In brief
This study addresses a "lifespan approach to healthy development and aging" with direct relevance to humans by testing the anti-aging effects of acarbose in humans. It is a pilot study to: i) better estimate power for a larger trial, ii) establish the safety and potential beneficial effects of acarbose in non-diabetic elderly humans, and iii) determine whether the effects of acarbose on the microbiome likely play a role in its enhancement of longevity and/or healthy aging. These are essential initial steps for translating acarbose into an anti-aging human therapy.
Key facts
- Study ID
- NCT02865499
- Run by
- The University of Texas Health Science Center at San Antonio
- People needed
- 8
- Starts
- 2016-06-01
- Expected to finish
- 2017-10-01
- Last updated by the study team
- 2019-03-14
Who can join
Age: 70 and older, up to 95. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- age 70-95
- participants will be in good health with all chronic diseases (hypertension, coronary artery disease, etc.) clinically stable.
- participants must have adequate cognitive function to be able to give informed consent. This will be established by enrolling participants with CLOX 1 scores of ≥10.
You may not qualify if…
- unstable ischemic heart disease
- clinically significant pulmonary disease
- history of immunodeficiency or receiving immunosuppressive therapy
- history of a coagulopathy or receiving a medical condition requiring anticoagulation
- an estimated glomerular filtration rate of <30ml/min
- uncontrolled hypercholesteremia >350mg/dl;
- uncontrolled hypertriglyceridemia >500mg/dl
- diabetes
- history of skin ulcers or poor wound healing
- smoking
- liver disease treatment with drugs known to affect cytochrome P450 3A (diltiazem, erythromycin)
Where it is running
- UTHSCSA — San Antonio, Texas, United States
Full record on ClinicalTrials.gov
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