Impact of Combined Behavioral Interventions on Cognitive Outcomes in MCI

Completed · Not applicable

Conditions studied: Mild Cognitive Impairment

In brief

Vast evidence supports use of physical exercise and cognitive stimulation for lowering risk for cognitive decline and dementia, with combinations of non-pharmacological interventions providing greatest promise for impacting cognitive aging. This, paired with limited cognitive benefits from pharmacological interventions in dementia, has shifted focus to non-pharmacological interventions administered earlier in the disease course. This application, therefore, proposes a randomized controlled trial (RCT; 12-week active intervention, 3- and 6-month follow-up) comparing 3 conditions: walking program (guided progressive increases in weekly step counts), computer-based cognitive training program (Brain HQ, Posit Science), and combination of the exercise and cognitive program, on cognitive, functional, and diagnostic outcomes in 60 sedentary, community-dwelling adults with mild cognitive impairment (MCI).

Key facts

Study ID

NCT02864069

Run by

University of California, San Diego

People needed

52

Starts

2014-09-01

Expected to finish

2018-10-01

Last updated by the study team

2020-01-18

Who can join

Age: 60 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• MCI diagnosis (can be self referral, will determine eligibility at baseline)

You may not qualify if…

• Dementia diagnosis
• Head trauma
• Neuro/psychiatric disorders
• Current substance dependence
• Sensory/mobility deficits
• No more than 1 hour of purposeful, aerobic activity/week
• Currently engaging in any other brain-stimulating computer program (No more than 1 hour a week)

Where it is running

• UCSD — La Jolla, California, United States

Full record on ClinicalTrials.gov

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