A Study of Prexasertib (LY2606368) in Combination With Ralimetinib in Participants With Advanced or Metastatic Cancer

Completed · Phase 1

Conditions studied: Advanced Cancer, Metastatic Cancer, Colorectal Cancer, Non-small Cell Lung Cancer

In brief

The main purpose of this study is to evaluate the safety of the study drug prexasertib in combination with ralimetinib in participants with advanced or metastatic cancer.

Key facts

Study ID

NCT02860780

Run by

Eli Lilly and Company

People needed

9

Starts

2016-08-10

Expected to finish

2017-05-15

Last updated by the study team

2018-12-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Advanced or metastatic cancer.
• Able to swallow tablets.
• For Part B, you will need to have colon cancer or non-small cell lung (NSCLC) cancer with KRAS and/or BRAF mutations.
• Discontinued all previous treatments for cancer and recovered from the acute effects from the therapy.

You may not qualify if…

• Active infection (fungal, viral, or bacterial).
• Active cancer in your brain or spinal cord.
• Acute or chronic leukemia.
• Serious heart condition.
• Disease that requires immunosuppressant therapy.
• Diagnosis of inflammatory bowel disease.
• Major small bowel resection that interferes with your body's ability to absorb the oral medicine.
• Participated in other clinical trials investigating prexasertib or ralimetinib.
• Pregnant or breastfeeding.
• Other pre-existing conditions or medical history which your doctor will explain to you.

Where it is running

• Carolinas Medical Center — Charlotte, North Carolina, United States
• Sarah Cannon Research Institute SCRI — Nashville, Tennessee, United States
• For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. — Cologne, Germany

Full record on ClinicalTrials.gov

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