Blood Ropivacaine Concentrations Following Chest Wall Nerve Block Continuous Infusion

Stopped early

Conditions studied: Pain, Postoperative

In brief

The main objective of this proposed investigation is to evaluate blood ropivacaine concentrations in infants and toddlers following the initiation of, and over the course of, continuous paravertebral nerve blockade using ropivacaine infusion for postoperative pain control following esophageal atresia repair procedures that include posterior tracheopexy. Continuous unilateral chest wall nerve blockade (CUCWNB) using ropivacaine is the current standard of practice for this surgical population at the investigators' institution and, as such, this study does not aim to alter the current standard clinical care received by participants but rather evaluate the blood concentrations of ropivacaine as it is routinely used.

Key facts

Study ID

NCT02860091

Run by

Boston Children's Hospital

People needed

26

Starts

2018-10-01

Expected to finish

2026-05-14

Last updated by the study team

2026-05-18

Who can join

Age: any, up to 4. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Infants and toddlers (0-4) years
• Undergoing a procedure that requires a thoracotomy for esophageal atresia repair and related procedures
• Receiving ropivacaine via continuous paravertebral nerve block catheter or erector spinae catheter

You may not qualify if…

• Hepatic dysfunction
• Local anesthetic allergy

Where it is running

• Boston Children"S Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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