Human Biological Responses to Low Level Ozone

Completed · Not applicable

Conditions studied: Environmental Exposure, Nasal Inflammation

In brief

To investigate if low level ozone exposure will cause measurable inflammation in nasal cells.

Key facts

Study ID

NCT02857283

Run by

University of North Carolina, Chapel Hill

People needed

15

Starts

2017-04-22

Expected to finish

2019-07-01

Last updated by the study team

2021-05-14

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Males and females between 18 and 50 years of age.
• Vital signs within normal limits on admission to the study: Peripheral oxygen saturation (SpO2) > 94%, systolic blood pressure between 150-90 mm Hg, diastolic blood pressure between 100-60 mm Hg, afebrile.
• Forced Expiratory Volume (FEV1) of at least 80% of predicted.

You may not qualify if…

• Any chronic medical condition considered by the PI as a contraindication to the exposure study, including significant cardiovascular disease, diabetes requiring medication, chronic renal disease, chronic thyroid disease, or kidney disease.
• Use of systemic or inhaled steroids.
• Use of NSAID or aspirin within 7days of each study visit, and inability to withhold these medications prior to each session of the study.
• Pregnant or nursing women
• Use of cigarettes or other inhaled nicotine products within the past year, or more than a lifetime 5 pack year history of cigarette smoking.

Where it is running

• Center for Environmental Medicine, Asthma and Lung Biology — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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