Unlock the Cell: Castleman's Disease Flow Cytometry Study
Completed
Conditions studied: Castleman Disease, Angiofollicular Lymphoid Hyperplasia, GLNH, Hyperplasia, Castleman's Disease, Angiofollicular Lymph Hyperplasia, Giant Lymph Node Hyperplasia
In brief
Castleman disease, a rare lymphoproliferative disorder, is characterized by inflammatory cytokine production and multiple organ system dysfunction. In this study, we will investigate inflammatory markers, cells, and signaling pathways in prospectively collected blood samples and/or buccal swabs or saliva using biochemical and RT-PCR techniques, proteomics, genomics, immunohistochemistry, storage for future use, cell culture treated with external stimuli, flow cytometry, and other molecular tests
Key facts
- Study ID
- NCT02853968
- Run by
- University of Pennsylvania
- People needed
- 130
- Starts
- 2016-02-01
- Expected to finish
- 2019-03-30
- Last updated by the study team
- 2020-03-26
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- CD patients: Individuals of any age who are diagnosed with or suspected by a physician to have CD, including those who do have the ability to consent and those who lack the ability to consent
- Related Disease: Individuals who state that they have a disease that is a "Related Disease". "Related Disease" means autoimmune, oncology, inflammatory/lymphoproliferative disorders and infectious diseases that are similar to Castleman
- Healthy Individuals: Individuals without a history of auto-immune, inflammatory, infectious disease or oncologic disorders.
You may not qualify if…
- All individuals whose medical or psychological conditions (such as a mental handicap) would, in the opinion of the Principal Investigator, compromise the subject's safety or successful participation in the study.
Where it is running
- University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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