Cell-Free DNA and RNA in Blood fromMetastatic Prostate Cancer Patients

Stopped early

Conditions studied: Hormone-Resistant Prostate Cancer, Metastatic Prostate Carcinoma, Prostate Adenocarcinoma

In brief

This research trial studies cell-free deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) in blood from patients with prostate cancer that does not respond to hormone therapy and has spread to other places in the body. Studying samples of blood from patients with prostate cancer may help doctors to learn more about the changes that occur in tumor cells over time and how they become resistant to anti-cancer drugs.

Key facts

Study ID

NCT02853097

Run by

University of Southern California

People needed

7

Starts

2016-06-14

Expected to finish

2020-09-27

Last updated by the study team

2021-04-05

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• A diagnosis of histologically confirmed prostate adenocarcinoma and falling into one of the following 5 groups:
• Currently receiving ADT (previously untreated for metastatic disease)
• These patients will be grouped into 3 cohorts: having received ADT for 3-6 months; for 1-2 years; and for > 3 years
• Scheduled to begin treatment with ADT (previously untreated for metastatic disease)
• Scheduled to begin treatment with enzalutamide (castration resistant / has received ADT / may have received abiraterone)
• Scheduled to begin treatment with abiraterone (castration resistant / has received ADT / may have received enzalutamide)
• Scheduled to begin treatment with docetaxel (castration resistant / has received ADT / has received enzalutamide and/or abiraterone)
• Have been diagnosed with either hormone-naive or castrate-resistant metastatic disease
• Ability and willingness to provide written and informed consent

You may not qualify if…

• Patients who receive combined ADT with docetaxel for hormone-naive metastatic prostate cancer
• Patients on intermittent ADT

Where it is running

• Los Angeles County-USC Medical Center — Los Angeles, California, United States
• USC / Norris Comprehensive Cancer Center — Los Angeles, California, United States
• Keck Medical Center of USC Pasadena — Pasadena, California, United States

Full record on ClinicalTrials.gov

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