A Phase 2, Double-blind, Placebo-controlled Study of the Efficacy and Safety of Belumosudil in Subjects With Moderate/Severe Chronic Plaque Psoriasis

Completed · Phase 2 · Has a placebo group

Conditions studied: Chronic Plaque Psoriasis

In brief

This is a phase 2, randomized, placebo-controlled, 2-period study to evaluate the safety, tolerability, and efficacy of belumosudil in adult subjects with moderate to severe chronic plaque psoriasis who are candidates for systemic therapy or phototherapy.

Key facts

Study ID

NCT02852967

Run by

Kadmon Corporation, LLC

People needed

110

Starts

2016-09-14

Expected to finish

2019-02-13

Last updated by the study team

2022-03-16

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult subjects between the ages of 18 and 65 years
• Able to provide written Informed Consent Form prior to the performance of any study-specific procedures
• Diagnosis of moderate to severe chronic plaque psoriasis and a candidate for systemic therapy or phototherapy
• PASI of ≥ 12 at screening and prior to the first dose of study drug, confirmed at Week 1 Day 1 (Baseline)
• ≥ 10% PASI body surface area involvement at screening and prior to the first dose of study drug, confirmed at Baseline
• Willing to avoid tanning devices
• Adequate bone marrow function:
• Absolute neutrophil count > 1500/mm\^3
• Hemoglobin > 9.0 g/dL
• Platelets > 100,000/mm\^3
• Adequate safety laboratory values:
• Serum total bilirubin within normal limits (WNL)
• Aspartate aminotransferase (AST) and alalnine aminotransferase (ALT) < 2 × upper limit of normal (ULN)
• Serum creatinine < 1.5 × ULN
• Female subjects of childbearing potential with a negative pregnancy test at screening. Females of childbearing potential were defined as sexually mature women without prior hysterectomy or who had any evidence of menses in the past 12 months. However, women who had been amenorrheic for 12 or more months were still considered to be of childbearing potential if the amenorrhea was possibly due to prior chemotherapy, antiestrogens, or ovarian suppression
• Women of childbearing potential (i.e., menstruating women) had to have a negative urine pregnancy test (positive urine tests were to be confirmed by serum test) documented within the 24-hour period prior to the first dose of study drug
• Sexually active women of childbearing potential enrolled in the study had to agree to use 2 forms of accepted methods of contraception during the course of the study and for 3 months after their last dose of study drug. Effective birth control included: (a) intrauterine device plus 1 barrier method; (b) on stable doses of hormonal contraception for at least 3 months (e.g., oral, injectable, implant, transdermal) plus one barrier method; and (c) 2 barrier methods. Effective barrier methods were male or female condoms, diaphragms, and spermicides (creams or gels that contained a chemical to kill sperm); or (d) a vasectomized partner
• For male patients who were sexually active and who were partners of premenopausal women: agreed to use 2 forms of contraception as defined above during the treatment period and for at least 3 months after the last dose of study drug
• Willing to complete all study measurements and assessments in compliance with the protocol

You may not qualify if…

• Non-plaque or drug-induced (antimalarials, lithium) psoriasis (If subject was taking angiotensin II receptor blockers or beta blockers doses must have been stable for 6 months prior to study entry)
• Used systemic corticosteroids within 12 weeks prior to study entry
• Used topical corticosteroids except to the face, groin, or scalp
• Used methotrexate, retinoids (such as acitretin), or calcineurin inhibitors (such as cyclosporine) within 4 weeks prior to study entry
• Phototherapy within 4 weeks prior to study entry
• Biologic therapies, including antibodies to IL-17; anti-tumor necrosis factor-alpha; and anti-IL-12 \& IL-23 within 3 months prior to study entry
• Current use of an inhibitor or inducer of CYP3A4
• Active viral, fungal, or bacterial skin infection (other than nail fungal infection).
• Pregnant or lactating woman
• History of gastrointestinal (GI) surgery including any bariatric surgery, or any GI condition that might interfere with drug absorption
• Participating in another study with an investigational drug or within 28 days or 5 half-lives of the investigational drug (whichever was longer) of study entry
• History or other evidence of severe illness or any other conditions that would make the subject, in the opinion of the investigator, unsuitable for the study
• Regular and/or excessive use of alcohol within 2 years prior to study entry defined as alcohol intake > 14 drinks per week in a man or > 7 drinks per week in a woman. Approximately 10 g of alcohol equaled one "drink" unit. One unit equaled 1 ounce of distilled spirits, one 12-ounce beer, or one 4-ounce glass of wine
• QT interval data corrected using Fridericia's formula (QTcF) > 450 msec (average of 3 readings) during screening
• Exposure to belumosudil or known allergy/sensitivity to belumosudil within the last 6 months prior to study entry or any other ROCK-2 inhibitor
• History or presence of any of the following:
• ALT or AST > 2.0 × ULN at screening
• Renal disease and/or serum creatinine > 1.5 × ULN at screening

Where it is running

• Alliance Dermatology and Mohs Center — Phoenix, Arizona, United States
• University of California, Irvine - Dermatology Clinical Research Center — Irvine, California, United States
• Dermatology Research Associates — Los Angeles, California, United States
• Renstar Medical Research — Ocala, Florida, United States
• Dawes Fretzin Dermatology Group — Indianapolis, Indiana, United States
• Dermatology Specialists Research — New Albany, Indiana, United States
• Dermatology Specialists Research — Louisville, Kentucky, United States
• Metro Boston Clinical Partners — Brighton, Massachusetts, United States
• Psoriasis Treatment Center of Central New Jersey — East Windsor, New Jersey, United States
• Sadick Research Group — New York, New York, United States
• Oregon Dermatology and Research Center — Portland, Oregon, United States
• Tennessee Clinical Research Center — Nashville, Tennessee, United States
• Suzanne Bruce and Associates — Katy, Texas, United States
• Austin Institute for Clinical Research — Pflugerville, Texas, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.