Use of Semen TEX101 to Improve Sperm Retrieval Rates for Men With Non-obstructive Azoospermia

Status unconfirmed · Not applicable

Conditions studied: Non-obstructive Azoospermia

In brief

The investigators hypothesize that sperm production varies with time in men with no sperm in semen (non-obstructive azoospermia, NOA) and that the semen protein, TEX101, is able to monitor these changes. The investigators further hypothesize that TEX101 levels may be used to predict the optimum time for microsurgical testicular sperm extraction (mTESE) to provide the highest successful rates of sperm retrieval.

Key facts

Study ID

NCT02851966

Run by

Mount Sinai Hospital, Canada

People needed

200

Starts

2016-02-01

Expected to finish

2020-12-01

Last updated by the study team

2019-03-12

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with NOA by standard clinical means with a minimum of 2 semen tests confirming that the man is azoospermic
• Ability to understand the study and consent
• Ability to deliver semen samples

You may not qualify if…

• Men do not have NOA
• Cannot understand the study and consent
• Cannot provide semen samples

Where it is running

• University of California, San Francisco — San Francisco, California, United States
• Weill Cornell Medical College — New York, New York, United States
• St. Mary's Hospital — Montreal, Quebec, Canada

Full record on ClinicalTrials.gov

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