Dexamethasone Solution for the Treatment of Oral Lichen Planus

Completed · Phase 2

Conditions studied: Lichen Planus

In brief

The objective of this single center, 4-week, open label randomized, phase II study is to evaluate and characterize the tolerability and clinical effectiveness of dexamethasone 0.5mg/5ml solution in a mucoadhesive vehicle (Mucolox™) for the treatment of oral lichen planus.

Key facts

Study ID

NCT02850601

Run by

Brigham and Women's Hospital

People needed

24

Starts

2017-02-07

Expected to finish

2019-12-20

Last updated by the study team

2021-06-14

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18 years and older.
• Patients with symptomatic oral lichen planus (worst VAS sensitivity score ≥ 7 over the last week).

You may not qualify if…

• Patients already on topical or systemic steroids.
• Inability to comply with study instructions.
• Uncontrolled intercurrent illness or psychiatric illness/social situations that would limit compliance with study requirements.
• VAS sensitivity score < 7.

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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