Genetic Testing and Phenotypic Characterization of Severely Obese Pediatric and Adult Volunteers
Completed
Conditions studied: Pro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene Mutations
In brief
The purpose of this screening study is to identify people who have a rare genetic cause of obesity - specifically three genetic variants (a change in the DNA structure) of the POMC, PCSK1 and LepR genes that are currently known to result in obesity. This screening study will not include any investigational drugs. You will be asked to provide a DNA sample and answer some questions about your medical history and hunger.
Key facts
- Study ID
- NCT02849977
- Run by
- Rhythm Pharmaceuticals, Inc.
- People needed
- 5966
- Starts
- 2016-09-28
- Expected to finish
- 2020-06-09
- Last updated by the study team
- 2022-11-15
Who can join
Age: 2 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Synexus Clinical Research US, Inc. - Phoenix Southeast — Chandler, Arizona, United States
- Clinical Research Advantage Inc. — Mesa, Arizona, United States
- Tucson Neuroscience Research - M3 Wake Research — Tucson, Arizona, United States
- Study site — Encino, California, United States
- PRI, LLC - Los Alamitos - M3 Wake Research — Los Alamitos, California, United States
- Axis Clinical Trails — Los Angeles, California, United States
- Axis Clinical Trials — Los Angeles, California, United States
- PRI, LLC - Newport Beach - M3 Wake Research — Newport Beach, California, United States
- Nemours Foundation Alfred Dupont Children's Hospital — Wilmington, Delaware, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- University of Florida — Gainesville, Florida, United States
- South Florida Clinical Trials — Hialeah, Florida, United States
- Translational Research Inst. for Metabolism and Diabetes — Orlando, Florida, United States
- Nemours Children's Hospital — Orlando, Florida, United States
- Palm Harbor Medical Associates - BTC - PPDS — Palm Harbor, Florida, United States
- Synexus Clinical Research US, Inc. - St. Petersburg — Pinellas Park, Florida, United States
- Synexus Clinical Research US, Inc. - Chicago — Chicago, Illinois, United States
- Maine Medical Partners Pediatric Specialty Care — Portland, Maine, United States
- Baystate Children's Hospital, Division of Pediatric Endocrinology — Springfield, Massachusetts, United States
- Helen DeVos Children's Hospital Healthy Weight Center — Grand Rapids, Michigan, United States
- Synexus Clinical Research US, Inc. - West Florissant Internists — Bridgeton, Missouri, United States
- Impact Clinical Trials - Las Vegas — Las Vegas, Nevada, United States
- University of New Mexico — Albuquerque, New Mexico, United States
- New York Clinical Trials-Brooklyn — Brooklyn, New York, United States
- Synexus Clinical Research US, Inc. - Simon Williamson Clinic, PC — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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