Transcranial Direct Current Stimulation (TDCS) as an Intervention for Patients With Traumatic Brain Injury

Running, not enrolling · Phase 2 · Has a placebo group

Conditions studied: Traumatic Brain Injury

In brief

The primary aim of this study is to assess the magnitude of transcranial direct current stimulation (tDCS) -induced cognitive and functional change in patients with mild traumatic brain injury. This study will also attempt to identify biomarkers associated with treatment response. Last, acceptability and tolerability of procedures will be assessed. To accomplish these aims, a randomized, double-blind, sham-controlled, parallel groups, pilot study will be conducted in which participants are assigned to 24 sessions of tDCS or sham stimulation offered concurrent with working memory training. Neural efficiency will be measured with electroencephalogram (EEG) pre and post-intervention.

Key facts

Study ID

NCT02849223

Run by

Minneapolis Veterans Affairs Medical Center

People needed

41

Starts

2016-07-01

Expected to finish

2026-09-01

Last updated by the study team

2025-10-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Veterans enrolled at the Minneapolis Veterans Affairs (VA) Health Care System
• Age of 18 and 65
• Sustained a mild traumatic brain injury more than 1 year ago.

You may not qualify if…

• Presence of a psychotic disorder
• Severely depressed
• Clinically unstable due to a hospitalization or medication change in the previous 4 weeks
• Mild substance use disorder in the last month
• Moderate to Severe substance use disorder in the last six months
• Behavioral problems that prevent participation in a group intervention
• Premorbid intellectual ability (IQ) below 70
• Unable to provide informed consent
• Have a guardian of person
• Have another existing neurological condition that impacts cognitive functioning
• Not fluent enough in English to understand testing procedures
• Have a medical condition that is incompatible with transcranial direct current stimulation.

Where it is running

• Minneapolis Veterans Affairs Health Care System — Minneapolis, Minnesota, United States

Full record on ClinicalTrials.gov

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