Sodium Nitrate to Improve Blood Flow

Completed · Phase 1

Conditions studied: Becker Muscular Dystrophy

In brief

Investigators recently showed that tadalafil restores functional sympatholysis in patients with Becker muscular dystrophy (BMD). If tadalafil restores functional sympatholysis in BMD via the NO-cyclic guanosine monophosphate pathway, then functional sympatholysis should also be restored by sodium nitrite- which is an indirect nitric oxide donor.

Key facts

Study ID

NCT02847975

Run by

Cedars-Sinai Medical Center

People needed

11

Starts

2013-10-01

Expected to finish

2014-12-01

Last updated by the study team

2018-08-06

Who can join

Age: 15 and older, up to 55. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Becker muscular dystrophy
• age 15-55 years of age
• ambulatory

You may not qualify if…

• hypertension, diabetes, or heart failure by standard clinical criteria
• elevated brain natriuretic peptide level (>100 pg/ml)
• Left ventricular ejection fraction < 50%
• cardiac rhythm disorder, specifically: rhythm other than sinus, supraventricular tachycardia, atrial fibrillation, ventricular tachycardia, heart block
• continuous ventilatory support
• liver disease
• renal impairment
• history of asthma or bronchospasm
• use of any medications other than common supplements
• unable to perform handgrip exercise

Where it is running

• Cedars-Sinai Heart Institute — Los Angeles, California, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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