Effect of Proton Pump Inhibitors on Gut Microbiota and Systemic Inflammation in Older Adults

Completed · Early Phase 1

Conditions studied: Healthy Volunteers

In brief

The purpose of this study is to evaluate the effects of a common over-the-counter medication, omeprazole, on the normal gut bacteria and inflammation in the body in healthy older adults.

Key facts

Study ID

NCT02844621

Run by

The University of Texas Health Science Center at San Antonio

People needed

25

Starts

2016-05-01

Expected to finish

2016-12-01

Last updated by the study team

2017-01-20

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 60 years or older

You may not qualify if…

• No prior major gastrointestinal surgery
• No chronic daily use or any use within the past two months of the following medications: antibiotics, proton pump inhibitors, other acid reflux medications, probiotics, anti-inflammatory medications, anti-diarrhea medications, laxatives, anti-depressants, anti-anxiety medications, steroids, metformin, or biologic/immune modulating drugs

Where it is running

• First Outpatient Research Unit, Medical Arts and Research Center — San Antonio, Texas, United States

Full record on ClinicalTrials.gov

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