Improving Pulmonary Function Following Radiation Therapy

Completed · Not applicable

Conditions studied: Non-Small Cell Lung Cancer

In brief

The purpose of this study is to develop radiation plans that will help preserve lung function in healthy tissue surrounding the tumor. We believe that 4DCT scans can be useful in designing radiation treatment plans that help us avoid healthy normal functioning lung tissue close to lung tumors. Currently 4DCT scans are used to help us determine exactly where the tumor is and how it moves when you breathe. In this study we will also use the 4DCT scans to try to identify high functioning normal lung tissue.

Key facts

Study ID

NCT02843568

Run by

University of Wisconsin, Madison

People needed

122

Starts

2016-08-17

Expected to finish

2023-08-16

Last updated by the study team

2026-07-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologic diagnosis of non-small cell lung cancer or lung metastasis from a solid tumor. One biopsy site is adequate for multiple sites of thoracic disease.
• Treatment includes localized radiation therapy with or without chemotherapy
• Karnofsky ≥ 60%
• Not pregnant per radiation oncology standard procedures
• Ability to understand and the willingness to sign a written informed consent document

You may not qualify if…

• Prior (within last 6 months) or future planned therapeutic surgery for the treatment of the existing lung cancer
• Prior thoracic radiotherapy
• Severe COPD defined as disease requiring an inpatient stay for respiratory deterioration within the past 3 months
• Oxygen dependence of > 2 L/min continuously throughout the day at baseline
• Known underlying collagen vascular disease or intrinsic lung disease that could complicate expected sequelae of radiation (idiopathic pulmonary fibrosis, Wegener's granulomatosis)
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements.

Where it is running

• UW Johnson Creek — Johnson Creek, Wisconsin, United States
• University of Wisconsin Carbone Cancer Center — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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