Natural History of the Leukodystrophies

Completed

Conditions studied: Leukodystrophies

In brief

The purpose of this study is to: 1. define novel homogeneous groups of patients with LDs and 2. work toward finding the cause of these disorders.

Key facts

Study ID

NCT02843555

Run by

Baylor Research Institute

People needed

10

Starts

2019-01-23

Expected to finish

2019-01-23

Last updated by the study team

2019-03-22

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must:
• have clinical and radiographic signs of leukodystrophy without a specific etiology
• no diagnosis of adrenoleukodystrophy, adrenomyeloneuropathy, metachromatic leukodystrophy, Krabbe disease, Canavan disease, a well-defined amino acid organic acid disorder, or a systemic mitochondrial cytopathy.
• First-degree relatives of patients with leukodystrophies of unknown etiology (father, mother, siblings, or sons and daughters of the patients)
• Be able to travel to Baylor University Medical Center in Dallas Texas for evaluation and spend 5-8 working days on site
• Be able to tolerate a general exam and neurological exam
• Be able to tolerate a modest amount of blood drawing, provide a urine specimen, and have a skin biopsy(if not previously done)
• Be able to tolerate the performance of necessary neuroimaging studies to include EEG and Head MRI
• Be able to tolerate a neuropsychological testing and rehabilitation evaluation
• Be able to tolerate spinal tap or nerve biopsy if needed

You may not qualify if…

• Unable to travel to Baylor University Medical Center in Dallas Texas for evaluation
• Refusal to sign a study consent form
• Unable to tolerate the performance of the required testing

Where it is running

• Baylor University Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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