Using Exhaled Air to Determine Changes in Nutritional Status of Patients on Intravenous Nutrition

Completed

Conditions studied: Obesity, Malnourished, Fasting

In brief

Carbon-12 and carbon-13 are naturally-occurring isotopes that are found in exhaled breath. Investigators have proved that the 13CO2/12CO2 breath delta value (BDV) changes in subjects who were in negative energy balance then fed a positive energy balance meal. Measuring one liter of exhaled breath daily may be a more convenient way to measure negative or positive energy balance in patients receiving intravenous nutrition.

Key facts

Study ID

NCT02843256

Run by

University of Wisconsin, Madison

People needed

20

Starts

2016-06-08

Expected to finish

2017-07-10

Last updated by the study team

2017-11-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Anticipated start of parenteral nutrition
• Expected duration of stay at least 5 days from enrollment
• Subject speaks English
• Subjects with inability to take adequate oral nutrition who are developing or have developed malnutrition who require parenteral nutrition

You may not qualify if…

• Subjects unable to coordinate well enough to give a 1 liter breath sample
• Subjects receiving parenteral nutrition prior to admission
• Subjects who are pregnant
• Subjects who are prisoners
• Subjects who are pharmacologically sedated or with altered consciousness
• Subjects who are mechanically ventilated
• Subjects admitted for bone marrow or stem cell transplants
• Known participation in another interventional research study within 30 days prior to enrollment (note: to be eligible, any interventional treatment must have ended at least 30 days ago)
• Subjects with disease states or clinical conditions that do not make them study candidates, per the primary investigator's discretion

Where it is running

• University of Wisconsin Hospital and Clinics — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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