Checkpoint Blockade Immunotherapy Combined With Stereotactic Body Radiation in Advanced Metastatic Disease
Completed · Phase 2
Conditions studied: Metastatic Cancer
In brief
The purpose of this study is to determine whether stereotactic body radiation therapy (SBRT) combined with checkpoint blockaded immunotherapy (CBI) will improve the response to the anticancer treatment compared to CBI alone in patients with advanced metastatic cancer.
Key facts
- Study ID
- NCT02843165
- Run by
- University of California, San Diego
- People needed
- 106
- Starts
- 2016-09-02
- Expected to finish
- 2024-08-15
- Last updated by the study team
- 2025-09-30
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient has one lesion that is treatable with SBRT.
- Patient has at least 1 site of measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1 criteria on computed tomography (CT) or Magnetic resonance imaging (MRI) which will not be irradiated.
- Histological confirmation of malignancy (primary or metastatic tumor).
- Patient may have any prior therapy allowed aside from having had prior radiotherapy to the treatment site.
- Eastern Cooperative Oncology Group (ECOG) performance status ≤ 2.
- Patient's screening laboratory values must meet protocol limits.
- Patient must have the ability to understand and the willingness to sign a written informed consent document.
You may not qualify if…
- Patient has had chemotherapy or radiotherapy within 4 weeks prior to entering the study or those who have not recovered from adverse events due to agents administered more than 4 weeks earlier.
- Patient receiving any investigational or experimental agents other than immunotherapy.
- Patient who has had any prior radiotherapy to the treatment site(s).
- Patient is a pregnant woman (pregnant women are excluded from this study because radiation treatment has known potential for teratogenic or abortifacient effects).
- Patient refuses to sign informed consent.
Where it is running
- UCSD Moores Cancer Center — La Jolla, California, United States
Full record on ClinicalTrials.gov
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