Exercise Preconditioning and Breast Cancer Cardiotoxicity

Completed · Not applicable

Conditions studied: Breast Cancer

In brief

The purpose of this study is to determine whether a supervised exercise-training program, initiated prior to chemotherapy induction (pre-conditioning) and continued throughout chemotherapy treatment, can preserve short- and long-term cardiovascular performance, skeletal muscle function, cognitive ability and quality of life better than current standard or care recommendations for exercise during chemotherapy.

Key facts

Study ID

NCT02842658

Run by

Mayo Clinic

People needed

1

Starts

2016-04-01

Expected to finish

2019-10-18

Last updated by the study team

2020-02-24

Who can join

Age: 40 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must be able to communicate meaningfully with the investigator and must be legally competent to provide written informed consent
• Subjects will have been recently diagnosed with breast cancer (stage I, II or III)
• Subjects must be scheduled by their oncologist to undergo anthracycline based chemotherapy (doxorubicin and cyclophosphamide) in the neoadjuvant/adjuvant setting

You may not qualify if…

• Unstable angina
• Myocardial infarction in the past 4 weeks
• Uncompensated heart failure
• New York Heart Association class IV symptoms
• Complex ventricular arrhythmias
• Medical orthopedic conditions precluding stationary cycling
• Medical conditions precluding neuropsychological assessment
• Symptomatic severe aortic stenosis
• Acute pulmonary embolus
• Acute myocarditis
• Untreated high-risk proliferative retinopathy
• Recent retinal hemorrhage
• Uncontrolled hypertension
• Sodium and/or Potassium ≥ Grade 2
• Pregnant Women

Where it is running

• Mayo Clinic in Arizona — Scottsdale, Arizona, United States

Full record on ClinicalTrials.gov

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