Microbiome Fructan Metabolism and Symptoms in Childhood IBS

Completed · Not applicable

Conditions studied: Irritable Bowel Syndrome (IBS)

In brief

This study evaluates whether the gut microbiome is involved in determining whether children with irritable bowel syndrome (IBS) develop worsening GI symptoms (e.g. pain) when given fructans (a sugar often found in wheat). Participants will both receive a diet with fructans and a diet without fructans.

Key facts

Study ID

NCT02842281

Run by

Baylor College of Medicine

People needed

55

Starts

2014-09-01

Expected to finish

2019-12-01

Last updated by the study team

2021-01-22

Who can join

Age: 7 and older, up to 17. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children ages 7-17 years
• Children with IBS will meet Rome III criteria per the Rome III questionnaire
• Healthy children will not have chronic conditions
• English speaking and able to read/write in English

You may not qualify if…

• Previous bowel surgery
• Documented gastrointestinal disorder (e.g. ulcerative colitis)
• Serious chronic medical condition (e.g. diabetes)
• Weight and/or height are greater than or less than 2 standard deviations for age
• Chronic conditions with GI symptoms (e.g. cystic fibrosis)
• Antibiotics within the past 3 months
• Pregnancy
• Autism spectrum disorder and/or significant developmental delay
• Mood disorders (e.g. major depression)
• Known post-infectious etiology

Where it is running

• Children's Nutrition Research Center — Houston, Texas, United States
• Texas Children's Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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