Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty

Completed · Phase 4

Conditions studied: Osteoarthritis, Acetaminophen, Arthroplasty, Hip Replacement

In brief

The purpose of this study is to determine if intravenous acetaminophen is superior to oral acetaminophen when used as part of a multimodal pathway for primary total hip arthroplasty.

Key facts

Study ID: NCT02839876
Run by: Duke University
People needed: 81
Starts: 2017-03-14
Expected to finish: 2018-10-31
Last updated by the study team: 2021-03-09

Who can join

Age: 56 and older, up to 85. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Patients scheduled for elective, primary total hip replacement for osteoarthritis
American Society of Anesthesiologists (ASA) Physical Classification I-III
Weight 50 kg or greater
Body mass index 18-40 kg/m2

You may not qualify if…

Inability to consent to study
Inability to speak English
Pregnancy
Weight <50 kg
Revision hip replacement or emergency surgery
Contraindications to spinal anesthesia: coagulopathy or bleeding diathesis, local infection, allergy to local anesthetics
Allergies/intolerances/contraindications to any of the multimodal agents: acetaminophen, pregabalin, celecoxib, ketamine, or dexamethasone
Chronic pain from a separate source other than operative hip
Daily opioid equivalent use of 30 mg of morphine or greater at time of consent
History of heart failure
History of drug or alcohol abuse
Rheumatoid arthritis
Uncontrolled anxiety, schizophrenia or other psychiatric disorder that, in the opinion of the investigator, may interfere with the study assessments
Chronic malnutrition, renal or liver impairment
Hypersensitivity to acetaminophen or any of its excipients

Where it is running

Duke University Hospital — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

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