Effects of Spinal Cord Stimulation on Sensory Perceptions of Chronic Pain Patients

Completed · Not applicable

Conditions studied: Chronic Pain, Complex Regional Pain Syndrome, Failed Back Surgery Syndrome

In brief

It's well known that Spinal cord stimulation (SCS) changes the perception of chronic pain in the area stimulated by epidural electrodes. However, we don't know the effect of this type of stimulation on the perception of external sensations (temperature, touch, pressure, and vibration) and sharp pain. Quantitative sensory testing (QST) is used to quantify somatosensory phenotype. This QST battery tests different subtypes of nerve fibres (Aβ, Aδ and C) involved in the transduction of sensory information from the periphery to the spinal cord. The purpose of this study is to evaluate the effects of the SCS on sensory perceptions of patients with chronic pain (CRPS, FBSS). Sensorial perception tests will be carried out in accordance with a standardized procedure (Rolke et al. Pain, 2006). For non-implanted patients, an initial visit will be conducted before the operation. For all participants, two other visits will take place at least 6 months after the operation to perform the tests with and without stimulation.

Key facts

Study ID

NCT02837822

Run by

CHU de Quebec-Universite Laval

People needed

38

Starts

2015-10-01

Expected to finish

2018-05-01

Last updated by the study team

2018-07-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant with a diagnosis of CRPS or FBSS that meet International Association for the Study of Pain's criteria;
• Pain in one leg;
• Paresthesia area limited to the treated leg;
• No changes in the programming patterns of the device for a minimum of 30 days before the tests;
• Informed consent.

You may not qualify if…

• Wounds or infections at the painful site.

Where it is running

• University of Toledo Medical Center — Toledo, Ohio, United States
• CHU de Québec - Université Laval — Québec, Canada

Full record on ClinicalTrials.gov

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