Therapeutic Antibodies Against Prion Diseases From PRNP Mutation Carriers

Completed

Conditions studied: Prion Diseases

In brief

The human Prion diseases can be classified into sporadic, acquired and inherited forms. Inherited forms usually manifest in higher age so there have to be factors preventing Prion propagation in young mutation carriers. Antibodies against the flexible tail of Prions have been shown to be protective in mice. The investigators intend to screen mutation carriers and controls for the presence of Prion autoantibodies.

Key facts

Study ID

NCT02837705

Run by

University of Zurich

People needed

213

Starts

2015-09-01

Expected to finish

2019-03-01

Last updated by the study team

2023-05-24

Who can join

Age: 1 and older, up to 99. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Relatives of patients of genetic Prion diseases
• Obtained informed consent

You may not qualify if…

• No informed consent

Where it is running

• UCSF Memory and Aging Center — San Francisco, California, United States
• Medical University Graz — Graz, Austria
• University Medical Center Göttingen — Göttingen, Germany
• CJD Foundation Israel — Pardés H̱anna Karkur, Israel
• Istituto di Ricerche Farmacologiche — Milan, Italy
• Slovak Medical University — Bratislava, Slovakia
• Institute of Neuropathology — Zurich, Switzerland

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.