Safety and Efficacy Study of Herpes Simplex Virus Type 2 (HSV-2) Therapeutic DNA Vaccine

Completed · Phase 2 · Has a placebo group

Conditions studied: Herpes Genitalis

In brief

The purpose of this trial is to evaluate the safety and efficacy of a therapeutic DNA vaccine in adults with symptomatic herpes simplex virus type 2 (i.e., genital herpes).

Key facts

Study ID

NCT02837575

Run by

Vical

People needed

261

Starts

2016-09-01

Expected to finish

2018-12-01

Last updated by the study team

2019-02-27

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• HSV-2 seropositive
• A minimum of 1 year of reported history of genital herpes with recurrences.

You may not qualify if…

• History of receiving an investigational HSV vaccine
• Chronic illness for which a subject's immune system is suspected to be impaired or altered, such as cancer, autoimmune conditions, or diabetes
• Pregnant or breastfeeding

Where it is running

• Alabama Vaccine Research Clinic at University of Alabama at Birmingham — Birmingham, Alabama, United States
• Medical Center for Clinical Research — San Diego, California, United States
• QPS Broward Research — Hollywood, Florida, United States
• QPS Miami Research Associates — South Miami, Florida, United States
• Comprehensive Clinical Trials, LLC — West Palm Beach, Florida, United States
• University of Illinois — Chicago, Illinois, United States
• Indiana University Infectious Disease Research — Indianapolis, Indiana, United States
• Heartland Research Associates, LLC — Wichita, Kansas, United States
• Central Kentucky Research Associates, Inc. — Lexington, Kentucky, United States
• The Center for Pharmaceutical Research — Kansas City, Missouri, United States
• Rochester Clinical Research, Inc. — Rochester, New York, United States
• University of North Carolina (UNC) Institute of Global Health and Infectious Diseases — Chapel Hill, North Carolina, United States
• Clinical Research Associates, Inc. — Nashville, Tennessee, United States
• University of Utah School of Medicine - Division of Infectious Diseases — Salt Lake City, Utah, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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